{
    "accession": "MITE0000011",
    "status": "active",
    "changelog": [
        {
            "version": "1",
            "date": "2024-07-30",
            "contributors": [
                "0000-0002-6270-3874",
                "0000-0003-2992-1607",
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0002-9747-3423"
            ],
            "comment": "Initial entry. Reviewer 1 switched text of enzyme description and enzyme reaction description"
        },
        {
            "version": "2",
            "date": "2025-07-25",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Added cofactor information"
        },
        {
            "version": "3",
            "date": "2025-07-25",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Fixed RHEA ID."
        }
    ],
    "enzyme": {
        "name": "MpaG",
        "description": "O-methyltransferase",
        "references": [
            "doi:10.1128/AEM.03015-10"
        ],
        "databaseIds": {
            "uniprot": "F1DBB3",
            "genpept": "ADY00134.1",
            "mibig": "BGC0000104"
        },
        "cofactors": {
            "inorganic": [
                "FeS"
            ],
            "organic": [
                "SAM"
            ]
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Methylation"
            ],
            "description": "Catalyzes the O-methylation of demethylmycophenolic acid into mycophenolic acid",
            "reactionSMARTS": "[#6:21]\\[#6:16](-[#6:17]-[#6:18]-[#6:19](-[#8:20])=[O:22])=[#6:15]/[#6:12]-[c:2]1[c:1](-[#8:11])[c:6]2-[#6:7](=[O:10])-[#8:9]-[#6:8]-[c:5]2[c:4](-[#6:13])[c:3]1-[#8:14]>>[#6]-[#8:14]-[c:3]1[c:4](-[#6:13])[c:5]2-[#6:8]-[#8:9]-[#6:7](=[O:10])-[c:6]2[c:1](-[#8:11])[c:2]1-[#6:12]\\[#6:15]=[#6:16](/[#6:21])-[#6:17]-[#6:18]-[#6:19](-[#8:20])=[O:22]",
            "reactions": [
                {
                    "substrate": "C/C(=C\\Cc1c(O)c(C)c2c(c1O)C(=O)OC2)CCC(=O)O",
                    "products": [
                        "COc1c(C)c2c(c(O)c1C/C=C(\\C)CCC(=O)O)C(=O)OC2"
                    ],
                    "isIntermediate": false
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "Heterologous expression"
                ],
                "references": [
                    "doi:10.1002/cbic.201402600"
                ]
            },
            "databaseIds": {
                "rhea": "81843"
            }
        }
    ]
}