{
    "accession": "MITE0000009",
    "status": "active",
    "changelog": [
        {
            "version": "1",
            "date": "2024-07-30",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA",
                "0000-0003-3002-6458",
                "0000-0002-9747-3423"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Initial entry. Reviewer fixed substrate (was identical to product), changed CXSMARTS to normal SMARTS."
        },
        {
            "version": "2",
            "date": "2025-07-25",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Added cofactor information"
        }
    ],
    "enzyme": {
        "name": "MeiD",
        "description": "O-methyltransferase",
        "references": [
            "doi:10.1128/AEM.02262-09"
        ],
        "databaseIds": {
            "uniprot": "D6C4C6",
            "genpept": "ADC45587.1",
            "mibig": "BGC0000093"
        },
        "cofactors": {
            "inorganic": [
                "FeS"
            ],
            "organic": [
                "SAM"
            ]
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Methylation"
            ],
            "reactionSMARTS": "[#6:1]12-[#6:35]-[#6:24](-[#6:25]-[#6:26]3(-[#8:34]-1)-[#6:33]-[#6:32]-[#6:30](-[#6:31])-[#6:28](-[#6:29])-[#8:27]-3)-[#8:23]-[#6:21](=[#8:22])-[#6:20]1-[#6:12](-[#6:14]-[#6:15](-[#6:17](=[#6:19]-1)-[#6:18])-[#8:16])(-[#8:13])-[#6:10](-[#6:11])=[#6:9]-[#6:8]=[#6:7]-[#6:6](-[#6:36])-[#6:5]-[#6:4](-[#6:37])=[#6:3]-[#6:2]-2>>[#6:1]12-[#6:35]-[#6:24](-[#6:25]-[#6:26]3(-[#8:34]-1)-[#6:33]-[#6:32]-[#6:30](-[#6:31])-[#6:28](-[#6:29])-[#8:27]-3)-[#8:23]-[#6:21](=[#8:22])-[#6:20]1-[#6:12](-[#6:14]-[#6:15](-[#6:17](=[#6:19]-1)-[#6:18])-[#8:16]-[#6])(-[#8:13])-[#6:10](-[#6:11])=[#6:9]-[#6:8]=[#6:7]-[#6:6](-[#6:36])-[#6:5]-[#6:4](-[#6:37])=[#6:3]-[#6:2]-2",
            "reactions": [
                {
                    "substrate": "C12CC=C(CC(C=CC=C(C)C3(O)CC(O)C(C)=CC3C(=O)OC(CC3(OC(C)C(C)CC3)O1)C2)C)C",
                    "products": [
                        "C12CC(CC3(O1)CCC(C)C(C)O3)OC(=O)C1C(CC(C(=C1)C)OC)(O)C(C)=CC=CC(C)CC(C)=CC2"
                    ],
                    "isIntermediate": false
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "Knock-out studies"
                ],
                "references": [
                    "doi:10.1128/AEM.02262-09"
                ]
            }
        }
    ]
}